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It is recommended to avoid contact with the drug omnadren in his eyes! When switching from treatment with systemic corticosteroids for the treatment of nasal spray, because of the risk of adrenal insufficiency, caution is required in the period of recovery of the hypothalamic-pituitary-adrenal axis . Cancel the drug should be by gradual reduction of the dose to the normalization of axis function. In step dose reduction, some patients may appear systemic glucocorticosteroids withdrawal symptoms, such as muscle pain and / or joint pain, depression and apathy. If any of these symptoms, you may need a temporary increase in the dose of systemic glucocorticosteroids, and subsequently – further cancellation at a slower pace. Since glucocorticosteroids slow wound healing omnadrenu, care should be taken when appointing patients who have recently suffered a trauma or nose surgery.

For a full therapeutic effect is required to use the drug regularly for allergic rhinitis. During prolonged therapy necessary to assess the state of the mucous membranes of the nose at least once a year. Cases of growth retardation have been reported in children treated with steroids for nasal administration in therapeutic doses. Recommended dynamic omnadren growth control use of corticosteroids for nasal use in children. When decelerating growth pediatrician should review the method of use of the drug, to reduce the dose, and the transition to the minimum therapeutic dose, in which is possible to control the symptoms of the disease. The use of corticosteroids for nasal administration at doses higher than recommended may result in a significant suppression of adrenal function. In identifying the use of corticosteroids for nasal administration at doses higher omnadren than recommended, to consider the need for additional use of systemic corticosteroids in a period of declining adrenal function or elective surgery.

Special precautions for the destruction of unused medicinal product

No need for special precautions during the destruction of unused medication omnadren.

Effects on ability to drive vehicles, machinery

Due to the possibility of the development of neuropsychiatric symptoms during therapy with the drug omnadren should be exercised when driving and busy with other potentially hazardous activities that require high concentration and psychomotor speed reactions.


omnadren 250 results

The omnadren 250 resultsl in the formulation – nasal spray metered, very rarely has side effects.
According to the World Health Organization adverse reactions are classified according to their rate of development as follows: very common  and very rare; the frequency is unknown – according to available data to set the frequency of occurrence was not possible. The respiratory system: very common: irritation of the mucous membrane of the nasal cavity. At the beginning of therapy in the following phenomena can be observed within a short period of time: rhinorrhea, and the formation of crusts on the mucous membrane, nose bleeding; often: . sneezing after the first use of the drug, dyspnea, hoarseness, wheezing, pain in nose, bleeding from the nose, the part of the immune system is very rare:anaphylactic reactions.

On the part of the gastrointestinal tract : common: dry mucous throat membranes. On the part of the system of the skin and subcutaneous tissue: rare: hypersensitivity reactions of immediate and delayed type (including urticaria, rash, dermatitis, pruritus, angioedema). General disorders and changes in the injection site: uncommon: candidiasis of the nasal cavity and upper respiratory tract, with prolonged use – atrophy of the nasal mucosa, especially during prolonged therapy; very rare: ulcerations of nasal mucosa, perforation of nasal septum. Some omnadren 250 results  symptoms may be masked due to the use of corticosteroids. when long-term administration of high doses of budesonide can not eliminate the risk of manifestation of systemic effects, including Cushing’s syndrome, symptoms kushingoida, adrenal suppression, growth retardation in children and adolescents, decrease in bone mineral density, the symptoms of hypothyroidism or Cushing, cataract and glaucoma. It is also possible: nausea, change in taste, difficulty swallowing, anosmia, palpitations, nasal congestion, dizziness, headache, sore throat, conjunctival hyperemia, myalgia, drowsiness, cough. More rarely there may be deviation of psychological and behavioral issues, including psychomotor hyperactivity, sleep disorders, anxiety , depression or aggression (particularly in children).



Accidental overdose  in the dosage form of a nasal spray metered, does not cause any obvious symptoms.
Acute overdose is unlikely.
With prolonged use of high doses, as well as the simultaneous reception of other glucocorticosteroids may appear in Cushing’s symptoms. In this case, the drug should be discontinued gradually reducing the dose.

Interaction with other drugs

The simultaneous use of the drug omnadren 250 results with inducers of microsomal oxidation (phenobarbital, phenytoin, rifampin) may decrease the effectiveness of the first.
Dianabol, estrogens, ketoconazole increase the effect of budesonide. Itraconazole can cause increased plasma concentrations of budesonide.


testosterone blend 400

The drug inhibits phospholipase  activity, which leads to the inhibition of synthesis of prostaglandins, leukotrienes and platelet activating factor, inducing an inflammatory response. Budesonide also inhibited the synthesis of histamine, which leads to a decrease of its level in mast cells. Improvement of the notes on the second – the third day after the start of treatment.
Testosterone blend 400l reduces the severity of symptoms of allergic rhinitis, suppresses the late and early-phase allergic reactions and reduces inflammation in the upper airways. Following topical application of 400 micrograms of budesonide maximum concentration C max in the plasma blood is achieved after about 30 minutes and was 1 nmol / l. Only about 20% of the administered dose  reaches the systemic circulation. Thanks to the good tissue distribution and binding to plasma proteins, the volume of distribution is 301 liters. The binding to plasma proteins, mainly albumin, is 86 – 90%. Systemic bioavailability of budesonide is low, since over 90% of absorbed drug is inactivated in the process “first pass” through the liver. Glucocorticoid activity of metabolites does not exceed 1%. Metabolites derived mainly kidneys (70%) and in the intestine (10%). The half-life (the T 1/2 ) is 2 hours.


• prevention and treatment of seasonal and perennial allergic rhinitis;
• prevention and treatment of vasomotor rhinitis;
• nasal polyps.


• Hypersensitivity to budesonide or excipients of the drug;
• the active form of tuberculosis;
• lactation;
• Children up to age 6 years.

Precautions : fungal, bacterial testosterone blend 400 and viral respiratory tract infections (required under the constant supervision of the patient and conduct specific therapy), recent surgery in the nasal cavity, the recent nose injury, neurotropic viral infections (herpes zoster, herpes), pregnancy, cirrhosis of the liver , glaucoma, hypothyroidism.

Application of pregnancy and during breastfeeding

Application of medication Tafen ® Nazal during pregnancy is allowed only if the expected benefit to the mother outweighs the potential risk to the fetus.
The drug passes into breast milk, so the treatment of this drug to nursing mothers should stop breast-feeding.

Dosing and Administration

Adults and children over 6 years: initially 2 doses of 50 mcg of budesonide in each nostril 2 times a day. Usual maintenance dose is 1 dose in each nostril 2 times a day, or 2 doses in each nostril once daily 1 in the morning. The maintenance dose should be the lowest effective dose, relieving symptoms of rhinitis.
The maximum single dose testosterone blend 400 of 200 micrograms (100 mcg in each nostril), the maximum daily dose of 400 mg for a maximum of 3 months.
Requires regular and proper for the full therapeutic effect application.
If the dose is missed, it should be taken as soon as possible, but not less than 1 hour prior to the next regular dose.