Tamsulosin selectively and competitively blocks postsynaptic adrenoreceptors A1a located in the smooth muscle of the prostate, bladder neck and prostatic urethra. This leads to a reduction in smooth muscle tone of the prostate, bladder neck and prostatic urethra and detrusor improve function. This reduces the symptoms of obstruction and irritation associated with benign prostatic hyperplasia omnadren vs sustanon. Typically, the therapeutic effect develops within 2 weeks after receiving the drug, although some patients marked reduction of symptoms after the first dose. The ability to influence the tamsulosin A1A-adrenoceptors 20 times greater than its ability to interact with a1b – adrenoceptors are located in vascular smooth muscle. Due to such a high selectivity of the drug does not cause any clinically significant reduction in systemic blood pressure (BP) in both hypertensive patients and in patients with normal baseline blood pressure.
Absorption After oral tamsulosin is rapidly and almost completely absorbed from the gastrointestinal . This dosage form provides sustained and slow release of tamsulosin. Preparata- bioavailability of approximately 100%. Immediately after ingestion decreases the absorption of tamsulosin. Uniformity of absorption is increased if the patient is taking a drug every day after the same meal. After a single oral administration – 0.4 mg (after a hearty meal) the maximum concentration (Cmax) of the active substance in plasma is reached after 6 h equilibrium. state (after 5 days course of administration) Cmax value of the active substance in plasma at 60-70% higher than the Cmax after a single dose. The distribution of binding to plasma proteins – 90%. Tamsulosin has a slight volume of distribution (about 0.2 l / kg). Metabolism omnadren vs sustanon Tamsulosin is practically not subjected to the effect of “first pass” and slowly biotransformed in the liver with the formation of pharmacologically active metabolites that retain high selectivity to adrenoceptor. None of the metabolites is more active than the starting material – tamsulosin. Most of the active substance is present in blood in an unmodified form. When liver failure dose change is required. Excretion Tamsulosin and its metabolites are primarily excreted by the kidneys, and about 9% of the dose is excreted unchanged in. The single dose of tamsulosin -10 hours (at reception after a meal), after multiple dose -13 h, the final half-life – 22 hours.
Benign prostatic hyperplasia omnadren vs sustanon (treatment dizuricheskih disorders).
- The drug should not be administered to patients with hypersensitivity to tamsulosin or to other components of the drug;
- Orthostatic hypotension in history;
- Severe hepatic insufficiency.Precautions: severe renal impairment (creatinine clearance (CC) below 10 ml / min) (safety has not been proven). Pregnancy and lactation Tamsulosin is intended only for men.
Dosing and Administration
Inside, after the first meal, omnadren vs sustanon drinking plenty of water in a sitting or standing position. 0.4 mg (1 capsule) per day.
The capsule should not crush and grind.