The most important symptoms of overdose are the symptoms of the central nervous system: dizziness, confusion, lethargy, disorientation, drowsiness, as well as the response from the gastrointestinal tract.
In case of overdose, it is testosterone blend 250mg recommended to carry out gastric lavage (relates to tablets) and symptomatic therapy. There is no specific antidote.
The interaction with other drugs
Antacids containing aluminum hydroxide (including sucralfate) and magnesium, aluminum phosphate, zinc, iron reduces the absorption of ofloxacin. When receiving antacids and ofloxacin between their intake should be observed approximately a two-hour interval.
With the simultaneous use of vitamin K antagonists should be monitored for blood coagulation system.
Ofloxacin may slightly increase the plasma concentrations of glibenclamide, while using.
If you are using high doses of ofloxacin and other drugs that are excreted via renal tubular secretion, such as probenicid, cimetidine, furosemide, methotrexate, or may increase ofloxacin concentration in the serum.
in clinical studies revealed no pharmacokinetic interactions with theophylline ofloxacin. However, a significant lowering of the threshold for seizure activity could be observed in the appointment of quinolones in combination with theophylline, fenbufenom or other non-steroidal anti-inflammatory drugs, as well as other drugs, lowering the threshold for seizure activity.
In the appointment in conjunction with non-steroidal anti-inflammatory agents, derivatives of nitroimidazole and methylxanthines increases the risk of neurotoxic effects.
When concomitant administration with corticosteroids increases the risk of tendon rupture, particularly in elderly people.
When coadministered with drugs prolong the interval testosterone blend 250mg increases the risk interval prolongation.
in the appointment of drugs , alkalizing urine (carbonic anhydrase inhibitors, citrate, sodium bicarbonate), increases the risk of crystalluria and nephrotoxic effects.
- Renal failure
in connection with what is displayed ofloxacin mainly via the kidneys in patients with renal failure require dosage adjustment ofloxacin.
- Prevention of photosensitivity
during treatment with ofloxacin, due to the risk of photosensitivity, avoid exposure to bright sunlight and UV rays.
- Secondary infection
As with other antibiotics in the treatment, receiving ofloxacin, especially prolonged, can cause secondary infection associated with an increase in drug-resistant microorganisms. It needs re-evaluation of the patient’s condition. If a secondary infection occurs during therapy, appropriate measures should be taken.
- Pseudomembranous colitis
Occurrence of diarrhea, particularly in severe, persistent and / or mixed with blood, during or after treatment with ofloxacin may be a manifestation of pseudomembranous colitis. If you suspect that the development of pseudomembranous colitis treatment with ofloxacin must be discontinued immediately and appropriate specific antibiotic therapy (eg vancomycin inside, inside teicoplanin or metronidazole) should be instituted without delay. In this clinical situation are counter drugs that inhibit intestinal motility.
- Patients predisposed to occurrence of epileptic seizures
As with other quinolones, ofloxacin should be with great care given to patients predisposed to the development of epileptic seizures (patients with damage to the central nervous system in history, taking fenbufen and similar non-steroidal anti-inflammatory drugs, or drugs that lower the threshold for seizure activity, for example, theophylline).
Tendonitis, are very rare, can sometimes lead to tendon razrshu predominantly Achilles tendon, particularly in elderly patients. In the event of signs of tendonitis (tendon inflammation), should immediately stop treatment, immobilization of the Achilles tendon to produce and provide advice orthopedist.
- QT prolongation
is needed a certain caution when receiving fluoroquinolones, including ofloxacin, in patients with known risk factors for prolongation of the testosterone blend 250mg interval, such as:
- elderly age;
- uncorrectable electrolyte imbalance (eg, hypokalemia, hypo-magniemiya);
- congenital prolongation of the interval ;
- diseases of the cardiovascular system (heart failure, myocardial infarction, bradycardia)
- concomitant use of drugs prolonging the interval (IA and class III anti-arrhythmic drugs, tricyclic antidepressants, macrolides).
- Myasthenia gravis
Ofloxacin can lead to a worsening of myasthenia gravis.
Perhaps more frequent attacks of porphyria. During treatment with ofloxacin may cause false-positive results in the determination of opiates and porphyrin in the urine.
Ofloxacin inhibits release of Mycobacterium tuberculosis, leading to false negative results when bacteriological diagnosis of tuberculosis.Also during the period of treatment is not recommended to use ethanol.In applying the drug to women is not recommended to use tampons with an increased risk of developing thrush.Ofloxacin is not the drug of choice for pneumonia caused by pneumococcus.Not indicated in the treatment of acute testosterone blend 250mg tonsillitis.Driving or other mechanisms
Some side reactions such as dizziness, somnolence, and visual disturbances can reduce response and the ability to concentrate, and therefore increase the risk of situations in which the presence of these capabilities is particularly important (such as when driving or other mechanisms) .